A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex-Reference-Cited by-同舟云学术

A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex

Published:2017-06-02 Issue:6 Volume:3 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ma Honglei¹²,Duan Jingbo³,Ke Jiyuan²^ORCID,He Yuanzheng²,Gu Xin²,Xu Ting-Hai¹²^ORCID,Yu Hong³^ORCID,Wang Yonghong³,Brunzelle Joseph S.⁴,Jiang Yi¹,Rothbart Scott B.⁵,Xu H. Eric¹²,Li Jiayang³^ORCID,Melcher Karsten²^ORCID

Affiliation:

1. Key Laboratory of Receptor Research, VARI-SIMM Center, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China.

2. Center of Cancer and Cell Biology, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.

3. State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China.

4. Department of Molecular Pharmacology and Biological Chemistry, Life Sciences Collaborative Access Team, Synchrotron Research Center, Northwestern University, Argonne, IL 60439, USA.

5. Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Abstract

Rice D53 repression motif links two sites of TPL corepressors to mediate TPL oligomerization and nucleosome association.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of General Medical Sciences

National Natural Science Foundation of China

Shanghai Rising-Star Program

Ministry of Science and Technology of the People’s Republic of China

Ministry of Science and Technology

NSF

National Institutes of Health