Structures of closed and open conformations of dimeric human ATM-Reference-Cited by-同舟云学术

Structures of closed and open conformations of dimeric human ATM

Published:2017-05-05 Issue:5 Volume:3 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Baretić Domagoj¹^ORCID,Pollard Hannah K.²,Fisher David I.²,Johnson Christopher M.¹,Santhanam Balaji¹,Truman Caroline M.²,Kouba Tomas¹,Fersht Alan R.¹,Phillips Christopher²,Williams Roger L.¹^ORCID

Affiliation:

1. Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

2. Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Darwin Building, Cambridge CB4 0WG, UK.

Abstract

Electron cryomicroscopy suggests regulation of ATM by a dynamic equilibrium between open and closed dimers.

Funder

Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference58 articles.

1. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

2. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

3. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

4. Mechanisms of ATM Activation

5. The ATM gene and ataxia telangiectasia;Mavrou A.;Anticancer Res.,2008

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