Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses-Reference-Cited by-同舟云学术

Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses

Published:2015-07-03 Issue:6 Volume:1 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

LaFayette Shantelle L.¹,Houle Daniel²,Beaudoin Trevor²,Wojewodka Gabriella²,Radzioch Danuta²^ORCID,Hoffman Lucas R.³⁴,Burns Jane L.⁴,Dandekar Ajai A.³,Smalley Nicole E.³,Chandler Josephine R.⁵,Zlosnik James E.⁶^ORCID,Speert David P.⁶,Bernier Joanie⁷,Matouk Elias⁷,Brochiero Emmanuelle⁸,Rousseau Simon²,Nguyen Dao¹²⁷

Affiliation:

1. Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada.

2. Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.

3. Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

4. Department of Pediatrics, University of Washington, Seattle, WA 98195, USA.

5. Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.

6. Department of Pediatrics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.

7. McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.

8. Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec H2X 0A9, Canada.

Abstract

Cystic fibrosis–adapted Pseudomonas aeruginosa lasR quorum sensing mutants cause hyperinflammation contributing to chronic lung disease.

Funder

Cystic Fibrosis Canada

CIHR

Burroughs Wellcome Fund

National Institutes of Health

Cystic Fibrosis Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference109 articles.

1. Pathophysiology and management of pulmonary infections in cystic fibrosis;Gibson R. L.;Am. J. Resp. Crit. Care Med.,2003

2. Cystic fibrosis: A mucosal immunodeficiency syndrome;Cohen T. S.;Nat. Med.,2012

3. Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

4. Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

5. Evolutionary dynamics of bacteria in a human host environment

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