Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades

Author:

Gaudry Michael J.1,Jastroch Martin23ORCID,Treberg Jason R.14,Hofreiter Michael5,Paijmans Johanna L. A.5,Starrett James6,Wales Nathan7,Signore Anthony V.1,Springer Mark S.6,Campbell Kevin L.1ORCID

Affiliation:

1. Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.

2. Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Research Center for Environmental Health, Parkring 13, 85748 Garching, Germany.

3. Department of Animal Physiology, Faculty of Biology, Philipps University of Marburg, D-35032 Marburg, Germany.

4. Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.

5. Department of Biology, University of York, Heslington, York YO10 5DD, UK.

6. Department of Biology, University of California, Riverside, CA 92521, USA.

7. Centre for GeoGenetics, Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.

Abstract

Inactivation of uncoupling protein 1 is linked to shifts in metabolic rate, body size, and species richness of eight mammalian lineages.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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