Epigenetic plasticity and the hallmarks of cancer-Reference-Cited by-同舟云学术

Epigenetic plasticity and the hallmarks of cancer

Published:2017-07-21 Issue:6348 Volume:357 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Flavahan William A.¹^ORCID,Gaskell Elizabeth¹,Bernstein Bradley E.¹^ORCID

Affiliation:

1. Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, and Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Abstract

Cancer epigenetics in the driver's seat Recent cancer genome projects unexpectedly highlighted the role of epigenetic alterations in cancer development. About half of human cancers were found to harbor mutations in chromatin proteins. In a Review, Flavahan et al. propose that chromatin and epigenetic aberrations have the potential to confer on cells the full range of oncogenic properties represented in the classic “hallmarks” depiction of cancer. They suggest that genetic, environmental, and metabolic factors can make chromatin aberrantly permissive or restrictive. Permissive chromatin creates a state of “epigenetic plasticity,” which can activate oncogene expression or cell fate changes that drive cancer development. Science , this issue p. eaal2380

Funder

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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