Host DNases prevent vascular occlusion by neutrophil extracellular traps-Reference-Cited by-同舟云学术

Host DNases prevent vascular occlusion by neutrophil extracellular traps

Published:2017-12 Issue:6367 Volume:358 Page:1202-1206
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jiménez-Alcázar Miguel¹^ORCID,Rangaswamy Chandini¹^ORCID,Panda Rachita¹^ORCID,Bitterling Josephine¹,Simsek Yashin J.¹^ORCID,Long Andy T.¹^ORCID,Bilyy Rostyslav²^ORCID,Krenn Veit³,Renné Christoph⁴^ORCID,Renné Thomas¹⁵,Kluge Stefan⁶,Panzer Ulf⁷,Mizuta Ryushin⁸,Mannherz Hans Georg⁹^ORCID,Kitamura Daisuke⁸,Herrmann Martin¹⁰^ORCID,Napirei Markus⁹^ORCID,Fuchs Tobias A.¹⁵^ORCID

Affiliation:

1. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.

2. Danylo Halytsky Lviv National Medical University, Pekarska Street 69, 79010 Lviv, Ukraine.

3. Health Care Center for Histology, Cytology, and Molecular Diagnostics, Max-Planck-Straße 5, 54296 Trier, Germany.

4. Group Practice for Pathology Wiesbaden, Ludwig-Erhard-Straße 100, 65199 Wiesbaden, Germany.

5. Department of Molecular Medicine and Surgery, Karolinska Institute and University Hospital, Solna L1:00, 17176 Stockholm, Sweden.

6. Department of Intensive Care, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.

7. III. Medical Clinic, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.

8. Research Institute for Biomedical Sciences, Tokyo University of Science, Yamazaki 2669, Noda, Chiba 278-0022, Japan.

9. Department of Anatomy and Molecular Embryology, Medical Faculty, Ruhr-University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.

10. Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg, Department of Medicine 3, Universitätsklinikum Erlangen, Ulmenweg 18, 91054 Erlangen, Germany.

Abstract

Blood DNases hack the NET Neutrophil extracellular traps (NETs) are lattices of processed chromatin decorated with select secreted and cytoplasmic proteins that trap and neutralize microbes. However, their inappropriate release may do more harm than good by promoting inflammation and thrombosis. Jiménez-Alcázar et al. report that two deoxyribonucleases (DNases), DNASE1 and DNASE1L3, have partially redundant roles in degrading NETs in the circulation (see the Perspective by Gunzer). Knockout mice lacking these enzymes were unable to tolerate chronic neutrophilia, quickly dying after blood vessels were occluded by NET clots. Furthermore, the damage unleashed by clots during septicemia was enhanced when these DNases were absent. Science , this issue p. 1202 ; see also p. 1126

Funder

European Commission

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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