Co-regulatory networks of human serum proteins link genetics to disease-Reference-Cited by-同舟云学术

Co-regulatory networks of human serum proteins link genetics to disease

Published:2018-08-24 Issue:6404 Volume:361 Page:769-773
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Emilsson Valur¹²^ORCID,Ilkov Marjan¹^ORCID,Lamb John R.³,Finkel Nancy⁴^ORCID,Gudmundsson Elias F.¹^ORCID,Pitts Rebecca⁴^ORCID,Hoover Heather⁴^ORCID,Gudmundsdottir Valborg¹^ORCID,Horman Shane R.³^ORCID,Aspelund Thor¹⁵^ORCID,Shu Le⁶^ORCID,Trifonov Vladimir³^ORCID,Sigurdsson Sigurdur¹,Manolescu Andrei⁷^ORCID,Zhu Jun⁸,Olafsson Örn¹,Jakobsdottir Johanna¹,Lesley Scott A.³^ORCID,To Jeremy³^ORCID,Zhang Jia³^ORCID,Harris Tamara B.⁹^ORCID,Launer Lenore J.⁹,Zhang Bin⁸,Eiriksdottir Gudny¹,Yang Xia⁶^ORCID,Orth Anthony P.³,Jennings Lori L.⁴^ORCID,Gudnason Vilmundur¹¹⁰

Affiliation:

1. Icelandic Heart Association, Holtasmari 1, IS-201 Kopavogur, Iceland.

2. Faculty of Pharmacology, University of Iceland, 101 Reykjavik, Iceland.

3. Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

4. Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA 02139, USA.

5. Centre of Public Health Sciences, University of Iceland, 101 Reykjavik, Iceland.

6. Department of Integrative Biology and Physiology, University of California, Los Angeles CA, USA.

7. School of Science and Engineering, Mentavegur 1, IS-101, Reykjavik University, 101 Reykjavik, Iceland.

8. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

9. Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892-9205, USA.

10. Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.

Abstract

The blood proteome in disease Understanding the function of human blood serum proteins in disease has been limited by difficulties in monitoring their production, accumulation, and distribution. Emilsson et al. investigated human serum proteins of more than 5000 Icelanders over the age of 65. The composition of blood serum includes a complex regulatory network of proteins that are globally coordinated across most or all tissues. The authors identified modules and functional groups associated with disease and health outcomes and were able to link genetic variants to complex diseases. Science , this issue p. 769

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Neurological Disorders and Stroke

Fondation Leducq

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference68 articles.

1. The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays

2. Tissue-based map of the human proteome

3. Secreted proteins as a fundamental source for biomarker discovery