Structure of human TFIID and mechanism of TBP loading onto promoter DNA-Reference-Cited by-同舟云学术

Structure of human TFIID and mechanism of TBP loading onto promoter DNA

Published:2018-12-21 Issue:6421 Volume:362 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Patel Avinash B.¹²^ORCID,Louder Robert K.¹²^ORCID,Greber Basil J.²³^ORCID,Grünberg Sebastian⁴^ORCID,Luo Jie⁵^ORCID,Fang Jie⁶,Liu Yutong⁷^ORCID,Ranish Jeff⁵,Hahn Steve⁴^ORCID,Nogales Eva¹²⁶⁸^ORCID

Affiliation:

1. Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA.

2. Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

3. California Institute for Quantitative Biology (QB3), University of California, Berkeley, CA 94720, USA.

4. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

5. Institute for Systems Biology, Seattle, WA 98109, USA.

6. Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.

7. Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA.

8. Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

Abstract

Mechanism of promoter recognition To start transcription, RNA polymerase II is recruited by the general transcription factor IID (TFIID) to the DNA promoter. Patel et al. used a combination of experimental approaches to elucidate the full molecular architecture of human TFIID and its complete conformational landscape during promoter recognition. They suggest exactly how TFIID is loaded onto the promoter, which involves defined steps—including promoter recognition and transcription initiation—and leads to regulated gene expression. Science , this issue p. eaau8872

Funder

Howard Hughes Medical Institute

National Cancer Institute

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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