Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates

Author:

Liu Zhiyong1,Yang Ching-Po1,Sugino Ken1,Fu Chi-Cheng12,Liu Ling-Yu1,Yao Xiaohao1,Lee Luke P.2,Lee Tzumin1

Affiliation:

1. Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA, USA.

2. Departments of Bioengineering, Electrical Engineering, and Computer Science, and Biophysics Graduate Program, University of California Berkeley, 408C Stanley Hall, Berkeley, CA, USA.

Abstract

Changes over time build neuronal diversity Although neural progenitors can keep generating new neurons, they can generate different neurons as the organism develops. Two different sections of the Drosophila brain, the mushroom bodies and the antennal lobes, show this characteristic, although the antennal lobes produce more different types of neurons over development than do the mushroom bodies. Liu et al. identified two RNA-binding proteins that manage this change over development in both settings. Science , this issue p. 317

Funder

Howard Hughes Medical Institute

NIH/NIGMS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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