Pan-cancer single-cell landscape of tumor-infiltrating T cells-Reference-Cited by-同舟云学术

Pan-cancer single-cell landscape of tumor-infiltrating T cells

Published:2021-12-17 Issue:6574 Volume:374 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zheng Liangtao¹^ORCID,Qin Shishang²^ORCID,Si Wen¹^ORCID,Wang Anqiang³^ORCID,Xing Baocai⁴,Gao Ranran²^ORCID,Ren Xianwen²^ORCID,Wang Li²,Wu Xiaojiang³,Zhang Ji³,Wu Nan⁵^ORCID,Zhang Ning⁶^ORCID,Zheng Hong⁷,Ouyang Hanqiang⁸⁹^ORCID,Chen Keyuan⁸⁹^ORCID,Bu Zhaode³^ORCID,Hu Xueda²¹⁰^ORCID,Ji Jiafu³¹¹^ORCID,Zhang Zemin¹²^ORCID

Affiliation:

1. Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.

2. BIOPIC, Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing 100871, China.

3. Gastrointestinal Cancer Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China.

4. Department of Hepatopancreatobiliary Surgery I, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China.

5. Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China.

6. Department of Urology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China.

7. Department of Gynecologic Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China.

8. Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, China.

9. Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, Beijing 100191, China.

10. Analytical Biosciences Limited, Beijing 100084, China.

11. Department of Biobank, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China.

Abstract

An atlas of cancer-associated T cells The tumor microenvironment contains many different kinds of immune cells, the composition, function, and roles of which are unclear. Using single-cell RNA sequencing of T cells in 21 cancer types from more than 300 patients, Zheng et al . identified differences in transcript composition that could be used to catalog different T cell types (see the Perspective by van der Leun and Schumacher). These annotations identified the different roles of specific types of CD4 + and CD8 + T cells among the different tumor types. Some of these clusters revealed evidence for two developmental paths for T cells, one of which shows a trajectory toward the “exhausted” T cell state, knowledge of which may be useful in developing future cancer immunotherapies. —LMZ

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.

1. Molecular mechanisms of T cell co-stimulation and co-inhibition

2. Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

3. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

4. TOX is a critical regulator of tumour-specific T cell differentiation

5. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

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