TOX is a critical regulator of tumour-specific T cell differentiation-Reference-Cited by-同舟云学术

TOX is a critical regulator of tumour-specific T cell differentiation

Published:2019-06-17 Issue:7764 Volume:571 Page:270-274
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Scott Andrew C.,Dündar Friederike,Zumbo Paul,Chandran Smita S.,Klebanoff Christopher A.,Shakiba Mojdeh,Trivedi Prerak,Menocal Laura,Appleby Heather,Camara Steven,Zamarin Dmitriy,Walther Tyler,Snyder Alexandra,Femia Matthew R.,Comen Elizabeth A.,Wen Hannah Y.,Hellmann Matthew D.,Anandasabapathy Niroshana,Liu Yong,Altorki Nasser K.,Lauer Peter,Levy Olivier,Glickman Michael S.,Kaye Jonathan,Betel Doron,Philip Mary,Schietinger Andrea

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-019-1324-y.pdf

Reference45 articles.

1. Thommen, D. S. & Schumacher, T. N. T cell dysfunction in cancer. Cancer Cell 33, 547–562 (2018).

2. Baitsch, L. et al. Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients. J. Clin. Invest. 121, 2350–2360 (2011).

3. Schietinger, A. et al. Tumor-specific T cell dysfunction is a dynamic antigen-driven differentiation program initiated early during tumorigenesis. Immunity 45, 389–401 (2016).

4. Mognol, G. P. et al. Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells. Proc. Natl Acad. Sci. USA 114, E2776–E2785 (2017).

5. Philip, M. et al. Chromatin states define tumour-specific T cell dysfunction and reprogramming. Nature 545, 452–456 (2017).

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