Draft Genome of the Filarial Nematode Parasite
Brugia malayi
Author:
Ghedin Elodie12345, Wang Shiliang12345, Spiro David12345, Caler Elisabet12345, Zhao Qi12345, Crabtree Jonathan12345, Allen Jonathan E.12345, Delcher Arthur L.12345, Guiliano David B.12345, Miranda-Saavedra Diego12345, Angiuoli Samuel V.12345, Creasy Todd12345, Amedeo Paolo12345, Haas Brian12345, El-Sayed Najib M.12345, Wortman Jennifer R.12345, Feldblyum Tamara12345, Tallon Luke12345, Schatz Michael12345, Shumway Martin12345, Koo Hean12345, Salzberg Steven L.12345, Schobel Seth12345, Pertea Mihaela12345, Pop Mihai12345, White Owen12345, Barton Geoffrey J.12345, Carlow Clotilde K. S.12345, Crawford Michael J.12345, Daub Jennifer12345, Dimmic Matthew W.12345, Estes Chris F.12345, Foster Jeremy M.12345, Ganatra Mehul12345, Gregory William F.12345, Johnson Nicholas M.12345, Jin Jinming12345, Komuniecki Richard12345, Korf Ian12345, Kumar Sanjay12345, Laney Sandra12345, Li Ben-Wen12345, Li Wen12345, Lindblom Tim H.12345, Lustigman Sara12345, Ma Dong12345, Maina Claude V.12345, Martin David M. A.12345, McCarter James P.12345, McReynolds Larry12345, Mitreva Makedonka12345, Nutman Thomas B.12345, Parkinson John12345, Peregrín-Alvarez José M.12345, Poole Catherine12345, Ren Qinghu12345, Saunders Lori12345, Sluder Ann E.12345, Smith Katherine12345, Stanke Mario12345, Unnasch Thomas R.12345, Ware Jenna12345, Wei Aguan D.12345, Weil Gary12345, Williams Deryck J.12345, Zhang Yinhua12345, Williams Steven A.12345, Fraser-Liggett Claire12345, Slatko Barton12345, Blaxter Mark L.12345, Scott Alan L.12345
Affiliation:
1. Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. 2. The Institute for Genomic Research (TIGR) and the J. Craig Venter Institute, 9712 Medical Center Drive, Rockville, MD 20850, USA. 3. Division of Cell and Molecular Biology, Biochemistry Building, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK. 4. School of Life Sciences Research, University of Dundee, Dow Street, Dundee, DD1 5EH, UK. 5. Division of Parasitology, New England BioLabs, Inc., 240 County Road, Ipswich, MA 01938, USA.
Abstract
Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the ∼90 megabase (Mb) genome of the human filarial parasite
Brugia malayi
and predict ∼11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode
Caenorhabditis elegans
revealed that, despite these genes having maintained little conservation of local synteny during ∼350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of
B. malayi
to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its
Wolbachia
endosymbiont. These findings offer a foundation for rational drug design.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Cited by
543 articles.
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