Structure of a human catalytic step I spliceosome-Reference-Cited by-同舟云学术

Structure of a human catalytic step I spliceosome

Published:2018-02-02 Issue:6375 Volume:359 Page:537-545
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhan Xiechao¹^ORCID,Yan Chuangye¹^ORCID,Zhang Xiaofeng¹^ORCID,Lei Jianlin¹²,Shi Yigong¹³^ORCID

Affiliation:

1. Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

2. Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

3. Institute of Biology, Westlake Institute for Advanced Study, Westlake University, Shilongshan Road No. 18, Xihu District, Hangzhou 310064, Zhejiang Province, China.

Abstract

Structure of the human spliceosome Catalyzed by the spliceosome, precursor mRNA splicing proceeds in two steps: branching and exon ligation. Transition from the C (catalytic post-branching spliceosome) to the C* (catalytic pre-exon ligation spliceosome) complex is driven by the adenosine triphosphatase/helicase Prp16. Zhan et al. report the cryo-electron microscopy structure of the human C complex, showing that two step I splicing factors stabilize the active site and link it to Prp16. Science , this issue p. 537

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People"s Republic of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference67 articles.

1. The Spliceosome: Design Principles of a Dynamic RNP Machine

2. Mechanistic insights into precursor messenger RNA splicing by the spliceosome

3. A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis.

4. Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites

5. Structure of a yeast spliceosome at 3.6-angstrom resolution

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