Safeguards for Cell Cooperation in Mouse Embryogenesis Shown by Genome-Wide Cheater Screen

Abstract

Keeping Cells Cooperating Multicellular organisms have certain advantages over those that are single-celled. To evolve, however, they must surmount a persistent challenge: ensuring that their constituent cells cooperate with one another rather than “cheat” or compete with each other for resources. Dejosez et al. (p. 1511 , published online 12 September) performed a genome-wide screen in induced pluripotent stem cells to search for genes that promote cell cooperation. A number of genes were identified of which knockdown allowed competitive behavior to dominate. These genes formed a network centered on p53, topoisomerase 1, and olfactory receptors. Thus, a genetic mechanism may promote cooperation in the developing embryo.