Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1-Reference-Cited by-同舟云学术

Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1

Published:2006-07-28 Issue:5786 Volume:313 Page:523-526
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Keele Brandon F.¹²³⁴⁵,Van Heuverswyn Fran¹²³⁴⁵,Li Yingying¹²³⁴⁵,Bailes Elizabeth¹²³⁴⁵,Takehisa Jun¹²³⁴⁵,Santiago Mario L.¹²³⁴⁵,Bibollet-Ruche Frederic¹²³⁴⁵,Chen Yalu¹²³⁴⁵,Wain Louise V.¹²³⁴⁵,Liegeois Florian¹²³⁴⁵,Loul Severin¹²³⁴⁵,Ngole Eitel Mpoudi¹²³⁴⁵,Bienvenue Yanga¹²³⁴⁵,Delaporte Eric¹²³⁴⁵,Brookfield John F. Y.¹²³⁴⁵,Sharp Paul M.¹²³⁴⁵,Shaw George M.¹²³⁴⁵,Peeters Martine¹²³⁴⁵,Hahn Beatrice H.¹²³⁴⁵

Affiliation:

1. Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.

2. Laboratoire Retrovirus, UMR145, Institut de Recherche pour le Développement and Department of International Health, University of Montpellier I, 911 Avenue Agropolis, Boite Postale 64501, 34394 Montpellier Cedex 5, France.

3. Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2UH, UK.

4. Projet Prevention du Sida au Cameroun (PRESICA), Boite Postale 1857, Yaoundé, Cameroun.

5. Howard Hughes Medical Institute, 720 South 20th Street, KAUL 816, Birmingham, AL 35294, USA.

Abstract

Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus (SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes . Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P. t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic (group M) and nonpandemic (group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

1. Isolation and partial characterization of an HIV-related virus occurring naturally in chimpanzees in Gabon

2. Genetic organization of a chimpanzee lentivirus related to HIV-1

3. C. P. Groves, in Mammalian Species of the World: A Taxonomic and Geographic Reference, D. E. Wilson, D. M. Reader, Eds. (Smithsonian Institution Press, Washington, DC, ed. 2, 1993), pp. 243–277.

4. Simian Immunodeficiency Virus Infection of Chimpanzees

5. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes

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