Villification: How the Gut Gets Its Villi-Reference-Cited by-同舟云学术

Villification: How the Gut Gets Its Villi

Published:2013-10-11 Issue:6155 Volume:342 Page:212-218
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Shyer Amy E.¹,Tallinen Tuomas²³,Nerurkar Nandan L.¹,Wei Zhiyan²,Gil Eun Seok⁴,Kaplan David L.⁴,Tabin Clifford J.¹,Mahadevan L.²⁵⁶⁷⁸

Affiliation:

1. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

2. School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

3. Department of Physics and Nanoscience Center, University of Jyväskylä, FI-40014 Jyväskylä, Finland.

4. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

5. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

6. Department of Physics, Harvard University, Cambridge, MA 02138, USA.

7. Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.

8. Kavli Institute for Nanobio Science and Technology, Harvard University, Cambridge, MA 02138, USA.

Abstract

Intestinal Villus Formation The intestinal villi are essential elaborations of the lining of the gut that increase the epithelial surface area for nutrient absorption. Shyer et al. (p. 212 , published online 29 August; see the Perspective by

Simons

) show that in both the developing human and chick gut, the villi are formed in a step-wise progression, involving the sequential folding of the endoderm into longitudinal ridges, via a zigzag pattern, to finally form individual villi. These changes are established through the differentiation of the smooth muscle layers of the gut, restricting the expansion of the adjacent proliferating and growing endoderm and mesenchyme, generating compressive stresses that lead to the buckling and folding of the tissue.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. The Role of the Visceral Mesoderm in the Development of the Gastrointestinal Tract

2. Intestinal development and differentiation

3. Ultrastructure of the Platypus and Echidna Mandibular Glands

4. Cell specialization in the small intestinal epithelium of adult Xenopus laevis: Structural aspects;McAvoy J. W.;J. Anat.,1978

5. Gross, microscopic and ultrastructural study of the intestinal tube of Xenodon merremii Wagler, 1824 (Ophidia);Ferri S.;J. Anat.,1976

Cited by 475 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The morphology of internal elastic lamina corrugations in arteries under physiological conditions;Morphologie;2024-12

2. Geometrical incompatibility regulated pattern selection and morphological evolution in growing spherical soft tissues;International Journal of Mechanical Sciences;2024-09

3. Photo-induced changes in tissue stiffness alter epithelial budding morphogenesis in the embryonic lung;2024-08-23

4. Tissue-scale in vitro epithelial wrinkling and wrinkle-to-fold transition;Nature Communications;2024-08-19

5. Active shape programming drives Drosophila wing disc eversion;Science Advances;2024-08-09