A Physical Map of 30,000 Human Genes
Author:
Deloukas P.1, Schuler G. D.1, Gyapay G.1, Beasley E. M.1, Soderlund C.1, Rodriguez-Tomé P.1, Hui L.1, Matise T. C.1, McKusick K. B.1, Beckmann J. S.1, Bentolila S.1, Bihoreau M.-T.1, Birren B. B.1, Browne J.1, Butler A.1, Castle A. B.1, Chiannilkulchai N.1, Clee C.1, Day P. J. R.1, Dehejia A.1, Dibling T.1, Drouot N.1, Duprat S.1, Fizames C.1, Fox S.1, Gelling S.1, Green L.1, Harrison P.1, Hocking R.1, Holloway E.1, Hunt S.1, Keil S.1, Lijnzaad P.1, Louis-Dit-Sully C.1, Ma J.1, Mendis A.1, Miller J.1, Morissette J.1, Muselet D.1, Nusbaum H. C.1, Peck A.1, Rozen S.1, Simon D.1, Slonim D. K.1, Staples R.1, Stein L. D.1, Stewart E. A.1, Suchard M. A.1, Thangarajah T.1, Vega-Czarny N.1, Webber C.1, Wu X.1, Hudson J.1, Auffray C.1, Nomura N.1, Sikela J. M.1, Polymeropoulos M. H.1, James M. R.1, Lander E. S.1, Hudson T. J.1, Myers R. M.1, Cox D. R.1, Weissenbach J.1, Boguski M. S.1, Bentley D. R.1
Affiliation:
1. P. Deloukas, C. Soderlund, A. Butler, C. Clee, T. Dibling, S. Gelling, L. Green, P. Harrison, R. Hocking, E. Holloway, S. Hunt, A. Mendis, A. Peck, D. Simon, R. Staples, D. R. Bentley, Sanger Centre, Hinxton Hall, Hinxton, Cambridge CB10 1SA UK. G. D. Schuler and M. S. Boguski, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA. G. Gyapay, S. Bentolila, N. Chiannilkulchai, N. Drouot, S. Duprat, C....
Abstract
A map of 30,181 human gene–based markers was assembled and integrated with the current genetic map by radiation hybrid mapping. The new gene map contains nearly twice as many genes as the previous release, includes most genes that encode proteins of known function, and is twofold to threefold more accurate than the previous version. A redesigned, more informative and functional World Wide Web site (
www.ncbi.nlm.nih.gov/genemap
) provides the mapping information and associated data and annotations. This resource constitutes an important infrastructure and tool for the study of complex genetic traits, the positional cloning of disease genes, the cross-referencing of mammalian genomes, and validated human transcribed sequences for large-scale studies of gene expression.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference52 articles.
1. Entrez Genomes at www.ncbi.nlm.nih.gov/Entrez/Genome/org.html 2. At the time of writing somewhat more than 5% of the human genome sequence is completed (J. Zhang O. Pickeral M. S. Boguski G. D. Schuler unpublished observations). 3. New Goals for the U.S. Human Genome Project: 1998-2003 4. These data are available through the High Throughput Genomic Sequences division of GenBank at www.ncbi.nlm.nih.gov/HTGS [ 5. Ouellette B. F. F., Boguski M. S., Genome Res. 7, 952 (1997);
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