Detection of human adaptation during the past 2000 years-Reference-Cited by-同舟云学术

Detection of human adaptation during the past 2000 years

Published:2016-11-11 Issue:6313 Volume:354 Page:760-764
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Field Yair¹²,Boyle Evan A¹,Telis Natalie³,Gao Ziyue¹²,Gaulton Kyle J.¹⁴,Golan David¹,Yengo Loic⁵⁶,Rocheleau Ghislain⁵,Froguel Philippe⁵⁷,McCarthy Mark I.⁴,Pritchard Jonathan K.¹²⁸

Affiliation:

1. Department of Genetics, Stanford University, Stanford, CA 94305, USA.

2. Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

3. Program in Biomedical Informatics, Stanford University, Stanford, CA 94305, USA.

4. Wellcome Trust Center for Human Genetics, and Oxford Center for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK.

5. Univ. Lille, CNRS, Institut Pasteur de Lille, UMR 8199–EGID, F-59000 Lille, France.

6. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.

7. Imperial College, Department of Genomics of Common Disease, London Hammersmith Hospital, London, UK.

8. Department of Biology, Stanford University, Stanford, CA, USA.

Abstract

Identifying genes under recent selection Evolutionary analyses aim to identify recent genetic changes that are likely to have been subject to selection. Field et al. present a method to identify such changes, the singleton density score, which they applied to over 3000 human genomes. Over the past ∼100 generations (2000 to 3000 years), Europeans are likely to have experienced selection for genetic variants, including those that affect skin and hair pigmentation, as well as height. Science , this issue p. 760

Funder

NIH

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference62 articles.

1. Detecting Natural Selection in Genomic Data

2. Genetic Signatures of Strong Recent Positive Selection at the Lactase Gene

3. SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans

4. Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

5. A Map of Recent Positive Selection in the Human Genome

Cited by 349 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Genetics of SLE;Dubois' Lupus Erythematosus and Related Syndromes;2025

2. Inferring polygenic negative selection underlying an individual trait as a distribution of fitness effects (DFEs) from GWAS summary statistics;2024-08-02

3. Reading children’s teeth to reconstruct life history and the evolution of human cooperation and cognition: The role of dental enamel microstructure and chemistry;Neuroscience & Biobehavioral Reviews;2024-08

4. A sequence of SVA retrotransposon insertions in ASIP shaped human pigmentation;Nature Genetics;2024-07-24

5. Polygenic selection to a changing optimum under self–fertilisation;PLOS Genetics;2024-07-17