Broad anti–SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination-Reference-Cited by-同舟云学术

Broad anti–SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination

Published:2022-03-04 Issue:6584 Volume:375 Page:1041-1047
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kaku Chengzi I.¹²^ORCID,Champney Elizabeth R.¹,Normark Johan³^ORCID,Garcia Marina⁴^ORCID,Johnson Carl E.¹,Ahlm Clas³^ORCID,Christ Wanda⁴^ORCID,Sakharkar Mrunal¹^ORCID,Ackerman Margaret E.²⁵^ORCID,Klingström Jonas⁴^ORCID,Forsell Mattias N. E.³^ORCID,Walker Laura M.¹⁶^ORCID

Affiliation:

1. Adimab, Lebanon, NH 03766, USA.

2. Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.

3. Division of Immunology, Department of Clinical Microbiology, Umeå University, Umeå, Sweden.

4. Centre for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

5. Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.

6. Adagio Therapeutics, Waltham, MA 02451, USA.

Abstract

Heterologous prime-boost immunization strategies have the potential to augment COVID-19 vaccine efficacy. We longitudinally profiled severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)–specific serological and memory B cell (MBC) responses in individuals who received either homologous (ChAdOx1:ChAdOx1) or heterologous (ChAdOx1:mRNA-1273) prime-boost vaccination. Heterologous messenger RNA (mRNA) booster immunization induced higher serum neutralizing antibody and MBC responses against SARS-CoV-2 variants of concern (VOCs) compared with that of homologous ChAdOx1 boosting. Specificity mapping of circulating B cells revealed that mRNA-1273 boost immunofocused ChAdOx1-primed responses onto epitopes expressed on prefusion-stabilized S. Monoclonal antibodies isolated from mRNA-1273–boosted participants displayed overall higher binding affinities and increased breadth of reactivity against VOCs relative to those isolated from ChAdOx1-boosted individuals. Overall, the results provide molecular insight into the enhanced quality of the B cell response induced after heterologous mRNA booster vaccination.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants

2. Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant

3. C. H. Hansen A. B. Schelde I. R. Moustsen-Helm H.-D. Emborg T. G. Krause K. Mølbak P. Valentiner-Branth Vaccine effectiveness against SARS-CoV-2 infection with the Omicron or Delta variants following a two-dose or booster BNT162b2 or mRNA-1273 vaccination series: A Danish cohort study. medRxiv 21267966 [Preprint] (2021).10.1101/2021.12.20.21267966 21267966

4. First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland

5. COVID ‐19 Vaccine‐Associated Cerebral Venous Thrombosis in Germany

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