Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer

Author:

Chan Yingguang Frank1,Marks Melissa E.1,Jones Felicity C.1,Villarreal Guadalupe1,Shapiro Michael D.1,Brady Shannon D.1,Southwick Audrey M.2,Absher Devin M.3,Grimwood Jane3,Schmutz Jeremy3,Myers Richard M.3,Petrov Dmitri4,Jónsson Bjarni5,Schluter Dolph6,Bell Michael A.7,Kingsley David M.1

Affiliation:

1. Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

2. Stanford Human Genome Center, Stanford University, Stanford, CA 94305, USA.

3. HudsonAlpha Institute, Huntsville, AL 35806, USA.

4. Department of Biology, Stanford University, Stanford, CA 94305, USA.

5. Institute of Freshwater Fisheries, Sæmundargata 1, 550 Sauðárkrókur, Iceland.

6. Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

7. Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794, USA.

Abstract

Adaptive Girdle Loss in Sticklebacks How do molecular changes give rise to phenotypic adaptation exemplified by the repeated reduction in the pelvic girdle observed in separate populations of sticklebacks? Now Chan et al. (p. 302 , published online 10 December) have identified the specific DNA changes that control this major skeletal adaptation. The key locus controlling pelvic phenotypes mapped to a noncoding regulatory region upstream of the Pituitary homeobox transcription factor 1 gene, which drives a tissue-specific pelvic enhancer. Multiple populations showed independent deletions in this region and enhancer function was inactivated. Reintroduction of the enhancer restored pelvic development in a pelvic-reduced stickleback.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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