Complete Genome Sequence of
Neisseria meningitidis
Serogroup B Strain MC58
Author:
Tettelin Hervé1, Saunders Nigel J.2, Heidelberg John1, Jeffries Alex C.2, Nelson Karen E.1, Eisen Jonathan A.1, Ketchum Karen A.1, Hood Derek W.2, Peden John F.2, Dodson Robert J.1, Nelson William C.1, Gwinn Michelle L.1, DeBoy Robert1, Peterson Jeremy D.1, Hickey Erin K.1, Haft Daniel H.1, Salzberg Steven L.1, White Owen1, Fleischmann Robert D.1, Dougherty Brian A.1, Mason Tanya1, Ciecko Anne1, Parksey Debbie S.1, Blair Eric1, Cittone Henry1, Clark Emily B.1, Cotton Matthew D.1, Utterback Terry R.1, Khouri Hoda1, Qin Haiying1, Vamathevan Jessica1, Gill John1, Scarlato Vincenzo3, Masignani Vega3, Pizza Mariagrazia3, Grandi Guido3, Sun Li2, Smith Hamilton O.1, Fraser Claire M.1, Moxon E. Richard2, Rappuoli Rino3, Venter J. Craig1
Affiliation:
1. The Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA. 2. Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, UK. 3. Immunological Research Institute of Siena (IRIS), Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy.
Abstract
The 2,272,351–base pair genome of
Neisseria meningitidis
strain MC58 (serogroup B), a causative agent of meningitis and septicemia, contains 2158 predicted coding regions, 1158 (53.7%) of which were assigned a biological role. Three major islands of horizontal DNA transfer were identified; two of these contain genes encoding proteins involved in pathogenicity, and the third island contains coding sequences only for hypothetical proteins. Insights into the commensal and virulence behavior of
N. meningitidis
can be gleaned from the genome, in which sequences for structural proteins of the pilus are clustered and several coding regions unique to serogroup B capsular polysaccharide synthesis can be identified. Finally,
N. meningitidis
contains more genes that undergo phase variation than any pathogen studied to date, a mechanism that controls their expression and contributes to the evasion of the host immune system.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Cited by
990 articles.
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