Affiliation:
1. From The Department of Bacteriology, Walter Reed Army Institute of Research, Washington, D. C. 20012
Abstract
High molecular weight group A and group C meningococcal polysaccharides had no significant toxicity for mice or guinea pigs. Furthermore, these polysaccharide preparations contained negligible amounts of biologically active endotoxin.
The high molecular weight group A and group C meningococcal polysaccharides were excellent immunogens in six human volunteers. Antibodies belonging to the immunoglobulin classes IgG, IgM, and IgA were produced.
These antibodies were highly meningococcocidal in the presence of complement.
Publisher
Rockefeller University Press
Subject
Immunology,Immunology and Allergy
Cited by
357 articles.
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