Affiliation:
1. European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Abstract
Malaria parasites must complete a complex developmental cycle in an
Anopheles
mosquito vector before transmission to a vertebrate host. Sexual development of the parasite in the midgut is initiated in the lumen immediately after the mosquito ingests infected blood, and the resulting ookinetes must traverse the surrounding epithelial layer before transforming into oocysts. The innate immune system of the mosquito is activated during midgut invasion, but to date, no evidence has been published identifying mosquito immune genes that affect parasite development. Here, we show by gene silencing that an
Anopheles gambiae
leucine rich-repeat protein acts as an antagonist and two C-type lectines act as protective agonists on the development of
Plasmodium
ookinetes to oocysts.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
359 articles.
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