Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population-Reference-Cited by-同舟云学术

Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population

Published:2002-10-04 Issue:5591 Volume:298 Page:213-216
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Niaré Oumou¹²,Markianos Kyriacos³,Volz Jennifer⁴,Oduol Frederick¹,Touré Abdoulaye²,Bagayoko Magaran²,Sangaré Djibril²,Traoré Sekou F.²,Wang Rui⁴,Blass Claudia⁴,Dolo Guimogo²,Bouaré Madama²,Kafatos Fotis C.⁴,Kruglyak Leonid³⁵,Touré Yeya T.²,Vernick Kenneth D.¹

Affiliation:

1. Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA.

2. Département d'Epidémiologie des Affectations Parasitaires, Faculté de Médecine, de Pharmacie et d'Odonto-Stomatologie, Boite Postale 1805, Bamako, Mali.

3. Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

4. European Molecular Biology Laboratories, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

5. Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA.

Abstract

Successful propagation of the malaria parasite Plasmodium falciparum within a susceptible mosquito vector is a prerequisite for the transmission of malaria. A field-based genetic analysis of the major human malaria vector, Anopheles gambiae , has revealed natural factors that reduce the transmission of P. falciparum . Differences in P. falciparum oocyst numbers between mosquito isofemale families fed on the same infected blood indicated a large genetic component affecting resistance to the parasite, and genome-wide scanning in pedigrees of wild mosquitoes detected segregating resistance alleles. The apparently high natural frequency of resistance alleles suggests that malaria parasites (or a similar pathogen) exert a significant selective pressure on vector populations.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Plasmodium falciparum sporozoites increase feeding-associated mortality of their mosquito hosts Anopheles gambiae s.l.

2. MALARIA-INDUCED APOPTOSIS IN MOSQUITO OVARIES

3. Plasmodium cynomolgi: Effects of malaria infection on laboratory flight performance of Anopheles stephensi mosquitoes

4. Genes identified by an expression screen of the vector mosquito Anopheles gambiae display differential molecular immune response to malaria parasites and bacteria

5. Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes

Cited by 114 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Late sporogonic stages of Plasmodium parasites are susceptible to the melanization response in Anopheles gambiae mosquitoes;Frontiers in Cellular and Infection Microbiology;2024-08-01

2. Late sporogonic stages ofPlasmodiumparasites are susceptible to the melanization response inAnopheles gambiaemosquitoes;2024-06-01

3. Case Report: Plasmodium vivax Sporozoite Melanization in the Midgut and Salivary Gland of the Malaria Vector Anopheles darlingi;The American Journal of Tropical Medicine and Hygiene;2024-03-06

4. Conceptual risk assessment of mosquito population modification gene-drive systems to control malaria transmission: preliminary hazards list workshops;Frontiers in Bioengineering and Biotechnology;2023-10-26

5. Vector-Parasite Interactions and Malaria Transmission;Mosquito Research - Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies;2023-01-04