A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome
Author:
Mural Richard J.1, Adams Mark D.1, Myers Eugene W.1, Smith Hamilton O.1, Miklos George L. Gabor2, Wides Ron3, Halpern Aaron1, Li Peter W.1, Sutton Granger G.1, Nadeau Joe4, Salzberg Steven L., Holt Robert A.1, Kodira Chinnappa D.1, Lu Fu1, Chen Lin1, Deng Zuoming1, Evangelista Carlos C.1, Gan Weiniu1, Heiman Thomas J.1, Li Jiayin1, Li Zhenya1, Merkulov Gennady V.1, Milshina Natalia V.1, Naik Ashwinikumar K.1, Qi Rong1, Shue Bixiong Chris1, Wang Aihui1, Wang Jian1, Wang Xin1, Yan Xianghe1, Ye Jane1, Yooseph Shibu1, Zhao Qi1, Zheng Liansheng1, Zhu Shiaoping C.1, Biddick Kendra1, Bolanos Randall1, Delcher Arthur L.1, Dew Ian M.1, Fasulo Daniel1, Flanigan Michael J.1, Huson Daniel H.1, Kravitz Saul A.1, Miller Jason R.1, Mobarry Clark M.1, Reinert Knut1, Remington Karin A.1, Zhang Qing1, Zheng Xiangqun H.1, Nusskern Deborah R.1, Lai Zhongwu1, Lei Yiding1, Zhong Wenyan1, Yao Alison1, Guan Ping1, Ji Rui-Ru1, Gu Zhiping1, Wang Zhen-Yuan1, Zhong Fei1, Xiao Chunlin1, Chiang Chia-Chien1, Yandell Mark1, Wortman Jennifer R.1, Amanatides Peter G.1, Hladun Suzanne L.1, Pratts Eric C.1, Johnson Jeffery E.1, Dodson Kristina L.1, Woodford Kerry J.1, Evans Cheryl A.1, Gropman Barry1, Rusch Douglas B.1, Venter Eli1, Wang Mei1, Smith Thomas J.1, Houck Jarrett T.1, Tompkins Donald E.1, Haynes Charles1, Jacob Debbie1, Chin Soo H.1, Allen David R.1, Dahlke Carl E.1, Sanders Robert1, Li Kelvin1, Liu Xiangjun1, Levitsky Alexander A.1, Majoros William H.1, Chen Quan1, Xia Ashley C.1, Lopez John R.1, Donnelly Michael T.1, Newman Matthew H.1, Glodek Anna1, Kraft Cheryl L.1, Nodell Marc1, Ali Feroze1, An Hui-Jin1, Baldwin-Pitts Danita1, Beeson Karen Y.1, Cai Shuang1, Carnes Mark1, Carver Amy1, Caulk Parris M.1, Center Angela1, Chen Yen-Hui1, Cheng Ming-Lai1, Coyne My D.1, Crowder Michelle1, Danaher Steven1, Davenport Lionel B.1, Desilets Raymond1, Dietz Susanne M.1, Doup Lisa1, Dullaghan Patrick1, Ferriera Steven1, Fosler Carl R.1, Gire Harold C.1, Gluecksmann Andres1, Gocayne Jeannine D.1, Gray Jonathan1, Hart Brit1, Haynes Jason1, Hoover Jeffery1, Howland Tim1, Ibegwam Chinyere1, Jalali Mena1, Johns David1, Kline Leslie1, Ma Daniel S.1, MacCawley Steven1, Magoon Anand1, Mann Felecia1, May David1, McIntosh Tina C.1, Mehta Somil1, Moy Linda1, Moy Mee C.1, Murphy Brian J.1, Murphy Sean D.1, Nelson Keith A.1, Nuri Zubeda1, Parker Kimberly A.1, Prudhomme Alexandre C.1, Puri Vinita N.1, Qureshi Hina1, Raley John C.1, Reardon Matthew S.1, Regier Megan A.1, Rogers Yu-Hui C.1, Romblad Deanna L.1, Schutz Jakob1, Scott John L.1, Scott Richard1, Sitter Cynthia D.1, Smallwood Michella1, Sprague Arlan C.1, Stewart Erin1, Strong Renee V.1, Suh Ellen1, Sylvester Karena1, Thomas Reginald1, Tint Ni Ni1, Tsonis Christopher1, Wang Gary1, Wang George1, Williams Monica S.1, Williams Sherita M.1, Windsor Sandra M.1, Wolfe Keriellen1, Wu Mitchell M.1, Zaveri Jayshree1, Chaturvedi Kabir1, Gabrielian Andrei E.1, Ke Zhaoxi1, Sun Jingtao1, Subramanian Gangadharan1, Venter J. Craig1
Affiliation:
1. Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA. 2. GenetixXpress, 81 Bynya Road, Palm Beach, Sydney, 2108, Australia. 3. Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. 4. Department of Genetics, Case Western Reserve University School of Medicine, Center for Computational Genomics, Case Western Reserve University, and Center for Human Genetics, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Abstract
The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Cited by
320 articles.
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