Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics-Reference-Cited by-同舟云学术

Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

Published:2014-03-07 Issue:6175 Volume:343 Page:1140-1144
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chang Wei-chen¹,Guo Yisong¹²,Wang Chen³,Butch Susan E.¹,Rosenzweig Amy C.⁴,Boal Amie K.¹³⁴,Krebs Carsten¹³,Bollinger J. Martin¹³

Affiliation:

1. Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.

2. Present address: Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.

3. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.

4. Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.

Abstract

Carbapenems Through the Looking Glass The carbapenem class of antibiotics is a critical weapon in the ongoing fight against drug-resistant bacteria. Microbial biosynthesis of these compounds, which contain a strained β-lactam ring motif, proceeds via a precursor that has the wrong configuration at one of the ring carbons. Chang et al. (p. 1140 ) combined x-ray crystallography with multiple spectroscopic probes to map out the mechanism by which the CarC enzyme inverts the precursor configuration to its mirror image.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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