An Unusual Ferryl Intermediate and Its Implications for the Mechanism of Oxacyclization by the Loline-Producing Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, LolO-Reference-Cited by-同舟云学术

An Unusual Ferryl Intermediate and Its Implications for the Mechanism of Oxacyclization by the Loline-Producing Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, LolO

Published:2024-06-20 Issue:13 Volume:63 Page:1674-1683
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Pan Juan¹^ORCID,Wenger Eliott S.¹^ORCID,Lin Chi-Yun¹^ORCID,Zhang Bo¹^ORCID,Sil Debangsu¹^ORCID,Schaperdoth Irene¹^ORCID,Saryazdi Setareh²,Grossman Robert B.²^ORCID,Krebs Carsten¹³^ORCID,Bollinger J. Martin¹³^ORCID

Affiliation:

1. Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States

2. Department of Chemistry, The University of Kentucky, Lexington, Kentucky 40506, United States

3. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States

Funder

Jane Coffin Childs Memorial Fund for Medical Research

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.4c00166

Reference55 articles.

1. Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes

2. From The Cover: SyrB2 in syringomycin E biosynthesis is a nonheme FeII -ketoglutarate- and O2-dependent halogenase

3. Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

4. Two Distinct Mechanisms for C–C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

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