Eight Calves Cloned from Somatic Cells of a Single Adult-Reference-Cited by-全球学者库

Eight Calves Cloned from Somatic Cells of a Single Adult

Published:1998-12-11 Issue:5396 Volume:282 Page:2095-2098
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kato Yoko¹,Tani Tetsuya¹,Sotomaru Yusuke¹,Kurokawa Kazuo¹,Kato Jun-ya¹,Doguchi Hiroshi¹,Yasue Hiroshi¹,Tsunoda Yukio¹

Affiliation:

1. Y. Kato, Y. Sotomaru, Y. Tsunoda, Laboratory of Animal Reproduction, College of Agriculture and Research Institute for Animal Developmental Biotechnology, Kinki University, 3327-204, Nakamachi, Nara, 631-8505, Japan. T. Tani, Laboratory of Animal Reproduction, College of Agriculture, Kinki University, 3327-204, Nakamachi, Nara, 631-8505, Japan. K. Kurokawa and J. Kato, Division of Molecular Oncology, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara, 630-0101, Japan. H. Doguchi...

Abstract

Eight calves were derived from differentiated cells of a single adult cow, five from cumulus cells and three from oviductal cells out of 10 embryos transferred to surrogate cows (80 percent success). All calves were visibly normal, but four died at or soon after birth from environmental causes, and postmortem analysis revealed no abnormality. These results show that bovine cumulus and oviductal epithelial cells of the adult have the genetic content to direct the development of newborn calves.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference21 articles.

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