Blastocyst Axis Is Specified Independently of Early Cell Lineage But Aligns with the ZP Shape-Reference-Cited by-同舟云学术

Blastocyst Axis Is Specified Independently of Early Cell Lineage But Aligns with the ZP Shape

Published:2007-05-04 Issue:5825 Volume:316 Page:719-723
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kurotaki Yoko¹²³⁴,Hatta Kohei¹²³⁴,Nakao Kazuki¹²³⁴,Nabeshima Yo-ichi¹²³⁴,Fujimori Toshihiko¹²³⁴

Affiliation:

1. Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8, Honcho, Kawaguchi, Saitama 332-0012, Japan.

3. Vertebrate Body Plan Group, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-minami-cho, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

4. Laboratory for Animal Resources and Genetic Engineering (LARGE), RIKEN CDB, 2-2-3 Minatojimaminami-cho, Chuo-ku Kobe, Hyogo 650-0047, Japan.

Abstract

The mechanisms controlling the establishment of the embryonic-abembryonic (E-Ab) axis of the mammalian blastocyst are controversial. We used in vitro time-lapse imaging and in vivo lineage labeling to provide evidence that the E-Ab axis of the mouse blastocyst is generated independently of early cell lineage. Rather, both the boundary between two-cell blastomeres and the E-Ab axis of the blastocyst align relative to the ellipsoidal shape of the zona pellucida (ZP), an extraembryonic structure. Lack of correlation between cell lineage and the E-Ab axis can be explained by the rotation of the embryo within the ZP.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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