1. Department of Pediatrics, University of Ioannina School of Medicine, Ioannina, 45110, Greece, and Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
2. Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece
3. Department of Medicine, Tufts Medical Center, and Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, MA 02111, USA
4. Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina 45110, Greece