Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements-Reference-Cited by-同舟云学术

Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements

Published:2018-03-02 Issue:6379 Volume:359 Page:1050-1055
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gu Bo¹^ORCID,Swigut Tomek¹,Spencley Andrew¹²^ORCID,Bauer Matthew R.¹,Chung Mingyu¹^ORCID,Meyer Tobias¹,Wysocka Joanna¹³⁴⁵^ORCID

Affiliation:

1. Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

4. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

5. Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Tracking regulatory DNA in action Cis-regulatory DNA elements such as enhancers and promoters are critical for transcription regulation. Little is known about the relationship between these elements' transcriptional activity and their mobility within the nucleus in living cells. Gu et al. developed a strategy to deliver multiple RNAs to guide inactive Cas9 to label these elements. Quantitative measurement of their movement during stem cell differentiation revealed that increased DNA loci mobility correlated with transcriptional activation. Science , this issue p. 1050

Funder

National Institutes of Health

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

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