Engineering of a light-gated potassium channel-Reference-Cited by-同舟云学术

Engineering of a light-gated potassium channel

Published:2015-05-08 Issue:6235 Volume:348 Page:707-710
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cosentino Cristian¹,Alberio Laura¹,Gazzarrini Sabrina¹,Aquila Marco¹,Romano Edoardo¹,Cermenati Solei¹,Zuccolini Paolo¹,Petersen Jan²,Beltrame Monica¹,Van Etten James L.³,Christie John M.²,Thiel Gerhard⁴,Moroni Anna¹

Affiliation:

1. Department of Biosciences, University of Milano, Italy.

2. Institute of Molecular, Cell and Systems Biology, University of Glasgow, UK.

3. Department of Plant Pathology and Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583-0900, USA.

4. Membrane Biophysics, Technical University of Darmstadt, Darmstadt, Germany.

Abstract

An optogenetic tool to silence neurons Potassium channels in the cell membrane open and close in response to molecular signals to alter the local membrane potential. Cosentino et al. linked a light-responsive module to the pore of a potassium channel to build a genetically encoded channel called BLINK1 that is closed in the dark and opens in response to low doses of blue light. Zebrafish embryos expressing BLINK1 in their neurons changed their behavior in response to blue light. Science , this issue p. 707

Funder

UK Biotechnology and Biological Sciences Research Council

Fondazione Cariplo

PRIN (Programmi di Ricerca di Rilevante Interesse Nazionale)

MAE (Ministero Affari Esteri)

Landes-Offensive zur Entwicklung Wissenschaftlich-ökonomischer Exzellenz (LOEWE)LOEWE

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

1. Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K + Channel