The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis-Reference-Cited by-同舟云学术

The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis

Published:2006-06-23 Issue:5781 Volume:312 Page:1802-1805
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Okada Kumiko¹²³⁴⁵,Inoue Akane¹²³⁴⁵,Okada Momoko¹²³⁴⁵,Murata Yoji¹²³⁴⁵,Kakuta Shigeru¹²³⁴⁵,Jigami Takafumi¹²³⁴⁵,Kubo Sachiko¹²³⁴⁵,Shiraishi Hirokazu¹²³⁴⁵,Eguchi Katsumi¹²³⁴⁵,Motomura Masakatsu¹²³⁴⁵,Akiyama Tetsu¹²³⁴⁵,Iwakura Yoichiro¹²³⁴⁵,Higuchi Osamu¹²³⁴⁵,Yamanashi Yuji¹²³⁴⁵

Affiliation:

1. Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113–8510, Japan.

2. School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113–8510, Japan.

3. Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108–8639, Japan.

4. Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113–0032, Japan.

5. The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852–8501, Japan.

Abstract

The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of neurotransmission. Dok-7, a MuSK-interacting cytoplasmic protein, is essential for MuSK activation in cultured myotubes; in particular, the Dok-7 phosphotyrosine-binding domain and its target in MuSK are indispensable. Mice lacking Dok-7 formed neither acetylcholine receptor clusters nor neuromuscular synapses. Thus, Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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