Phase separation provides a mechanism to reduce noise in cells-Reference-Cited by-同舟云学术

Phase separation provides a mechanism to reduce noise in cells

Published:2020-01-24 Issue:6476 Volume:367 Page:464-468
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Klosin A.¹^ORCID,Oltsch F.¹²^ORCID,Harmon T.¹³^ORCID,Honigmann A.¹⁴^ORCID,Jülicher F.²³⁴^ORCID,Hyman A. A.¹²⁴^ORCID,Zechner C.¹²⁴^ORCID

Affiliation:

1. Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

2. Center for Systems Biology Dresden, 01307 Dresden, Germany.

3. Max Planck Institute for the Physics of Complex Systems, 01187 Dresden Germany.

4. Cluster of Excellence Physics of Life, TU Dresden, 01062 Dresden, Germany.

Abstract

Keeping the noise down Protein concentrations in a cell fluctuate considerably because of stochasticity in gene expression and variations in the cell's microenvironment. How cells cope with concentration fluctuations when precision is important is unclear. Klosin et al. used a combination of theoretical and experimental work to demonstrate that phase-separated compartments can effectively reduce protein concentration noise in cells (see the Perspective by Riback and Brangwynne). The results suggest that phase separation provides a mechanism to enhance the robustness of biological systems. Science , this issue p. 464 ; see also p. 364

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Stochastic Gene Expression in a Single Cell

2. Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

3. Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise

4. Regulation of noise in the expression of a single gene

5. Biomolecular condensates: organizers of cellular biochemistry

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