Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles-Reference-Cited by-同舟云学术

Micellar Nanocontainers Distribute to Defined Cytoplasmic Organelles

Published:2003-04-25 Issue:5619 Volume:300 Page:615-618
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Savić Radoslav¹²,Luo Laibin¹²,Eisenberg Adi¹²,Maysinger Dusica¹²

Affiliation:

1. Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada.

2. Department of Chemistry, McGill University, Montreal, QC, H3A 2K6, Canada.

Abstract

Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs. An understanding of their cellular distribution is essential to achieving selective delivery of drugs at the subcellular level. Triple-labeling confocal microscopy in live cells revealed the localization of micelles in several cytoplasmic organelles, including mitochondria, but not in the nucleus. Moreover, micelles change the cellular distribution of and increase the amount of the agent delivered to the cells. These micelles may thus be worth exploring for their potential to selectively deliver drugs to specified subcellular targets.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference26 articles.

1. Drugs on Target

2. Liposomes Revisited

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