Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing-Reference-Cited by-同舟云学术

Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing

Published:2020-04-10 Issue:6487 Volume:368 Page:186-189
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bessman Nicholas J.¹²³^ORCID,Mathieu Jacques R. R.⁴⁵,Renassia Cyril⁴⁵,Zhou Lei¹²³,Fung Thomas C.¹²³^ORCID,Fernandez Keith C.¹²³^ORCID,Austin Christine⁶^ORCID,Moeller Jesper B.¹²³⁷^ORCID,Zumerle Sara⁴⁵^ORCID,Louis Sabine⁴⁵,Vaulont Sophie⁴⁵,Ajami Nadim J.⁸^ORCID,Sokol Harry⁹^ORCID,Putzel Gregory G.¹,Arvedson Tara¹⁰^ORCID,Sockolow Robbyn E.¹¹^ORCID,Lakhal-Littleton Samira¹²^ORCID,Cloonan Suzanne M.¹³¹⁴^ORCID,Arora Manish⁶,Peyssonnaux Carole⁴⁵^ORCID,Sonnenberg Gregory F.¹²³^ORCID

Affiliation:

1. Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, Cornell University, New York, NY, USA.

2. Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA.

3. Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.

4. Université de Paris, INSERM U1016, Institut Cochin, CNRS UMR8104, 75014 Paris, France.

5. Laboratory of Excellence GR-Ex, Paris, France.

6. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

7. Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

8. MD Anderson Cancer Center, Houston, TX, USA.

9. Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint Antoine, Service de Gastroenterologie, F-75012 Paris, France.

10. Department of Oncology Research, Amgen Inc., Thousand Oaks, CA, USA.

11. Department of Pediatrics, Division of Gastroenterology and Nutrition, Weill Cornell Medicine, Cornell University, New York, NY, USA.

12. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.

13. Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.

14. Trinity College Dublin, Dublin, Ireland.

Abstract

Ironing out the details of mucosal healing Anemia is a frequent complication of disorders such as inflammatory bowel disease, occurring in part as a result of increased bleeding into the intestine. Bessman et al. show that the peptide hormone hepcidin, which regulates systemic iron homeostasis, is required for intestinal repair in a mouse model of inflammatory bowel disease (see the Perspective by Rescigno). This effect was independent of hepatocyte-produced hepcidin and systemic iron levels. Instead, production of hepcidin by conventional dendritic cells was necessary and sufficient to promote local iron sequestration by macrophages, which in turn modulated the makeup of the gut microbiota to one with a more beneficial distribution of species. Science , this issue p. 186 ; see also p. 129

Funder

NIH Office of the Director

National Institute of Allergy and Infectious Diseases

European Research Council

Fondation pour la Recherche Médicale

National Institute of Environmental Health Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

Burroughs Wellcome Fund

Crohn"s and Colitis Foundation of America

American Asthma Foundation

Searle Scholars Program

Eunice Kennedy Shriver National Institute of Child Health and Human Development