Comparative Metagenomics of Microbial Communities

Author:

Tringe Susannah Green12345,von Mering Christian12345,Kobayashi Arthur12345,Salamov Asaf A.12345,Chen Kevin12345,Chang Hwai W.12345,Podar Mircea12345,Short Jay M.12345,Mathur Eric J.12345,Detter John C.12345,Bork Peer12345,Hugenholtz Philip12345,Rubin Edward M.12345

Affiliation:

1. Department of Energy (DOE) Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.

2. Lawrence Berkeley National Laboratory, Genomics Division, Berkeley, CA 94720, USA.

3. European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

4. University of California, Berkeley, Department of Electrical Engineering and Computer Science, Berkeley, CA 94720, USA.

5. Diversa Corporation, 4955 Directors Place, San Diego, CA 92121, USA.

Abstract

The species complexity of microbial communities and challenges in culturing representative isolates make it difficult to obtain assembled genomes. Here we characterize and compare the metabolic capabilities of terrestrial and marine microbial communities using largely unassembled sequence data obtained by shotgun sequencing DNA isolated from the various environments. Quantitative gene content analysis reveals habitat-specific fingerprints that reflect known characteristics of the sampled environments. The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

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