mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase-Reference-Cited by-同舟云学术

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mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

Published:2011-11-04 Issue:6056 Volume:334 Page:678-683
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zoncu Roberto¹²³⁴,Bar-Peled Liron¹²³,Efeyan Alejo¹²³,Wang Shuyu¹²³,Sancak Yasemin¹²³,Sabatini David M.¹²³⁴⁵

Affiliation:

1. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

2. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

3. David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

4. Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, USA.

5. Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.

Abstract

Cellular sensing of amino acids occurs at the lysosome and is mediated by the vacuolar proton pump.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. mTOR: from growth signal integration to cancer, diabetes and ageing

2. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

3. Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

4. Regulation of TORC1 by Rag GTPases in nutrient response

5. The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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