Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement-Reference-Cited by-同舟云学术

Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

Published:2011-07-15 Issue:6040 Volume:333 Page:348-353
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Isaacs Farren J.¹,Carr Peter A.²³,Wang Harris H.¹⁴⁵⁶,Lajoie Marc J.¹⁷,Sterling Bram²³,Kraal Laurens¹,Tolonen Andrew C.¹,Gianoulis Tara A.¹⁶,Goodman Daniel B.¹⁵,Reppas Nikos B.⁸,Emig Christopher J.⁹,Bang Duhee¹⁰,Hwang Samuel J.¹¹,Jewett Michael C.¹¹²,Jacobson Joseph M.²³,Church George M.¹⁶

Affiliation:

1. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

2. Center for Bits and Atoms, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4. Program in Biophysics, Harvard University, Cambridge, MA 02138, USA.

5. Program in Medical Engineering and Medical Physics, Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

6. Wyss Institute, Harvard University, Cambridge, MA 02115, USA.

7. Program in Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

8. Joule Unlimited, Cambridge, MA 02139, USA.

9. Department of Bioengineering, Stanford University, Palo Alto, CA 94305, USA.

10. Department of Chemistry, Yonsei University, Shinchon 134, Seoul 120-749, Korea.

11. Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

12. Department of Chemical and Biological Engineering and Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA.

Abstract

Template-mediated, genome construction and assembly created a strain with 80 precise codon changes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

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4. Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

5. Genome Transplantation in Bacteria: Changing One Species to Another

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