The mouse Sry locus harbors a cryptic exon that is essential for male sex determination-Reference-Cited by-同舟云学术

The mouse Sry locus harbors a cryptic exon that is essential for male sex determination

Published:2020-10-02 Issue:6512 Volume:370 Page:121-124
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Miyawaki Shingo¹²^ORCID,Kuroki Shunsuke¹²^ORCID,Maeda Ryo¹²,Okashita Naoki¹²,Koopman Peter³^ORCID,Tachibana Makoto¹²^ORCID

Affiliation:

1. Laboratory of Epigenome Dynamics, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan.

2. Division of Epigenome Dynamics, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-Cho, Tokushima, 770-8503, Japan.

3. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

Abstract

Two rather than one For several decades, it has been believed that the mammalian sex-determining gene Sry contains a single exon. Miyawaki et al. have now identified a cryptic second exon of mouse Sry . Loss- and gain-of-function analyses revealed that the two-exon SRY (SRY-T), not the canonical single exon–encoded SRY (SRY-S), is the bona fide testis-determining factor. Sry exon2 is composed of retrotransposon-derived sequences. The SRY-S carboxyl terminus contains a degradation sequence (degron), whereas the SRY-T carboxyl terminus encoded in the Sry exon2 is degron free, thereby conferring protein stability on SRY-T. Science , this issue p. 121

Funder

Japan Society for the Promotion of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

1. Male development of chromosomally female mice transgenic for Sry

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3. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

4. Inverted repeat structure of the Sry locus in mice.

5. Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a

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