Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a-Reference-Cited by-同舟云学术

Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a

Published:2013-09-06 Issue:6150 Volume:341 Page:1106-1109
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kuroki Shunsuke¹,Matoba Shogo²,Akiyoshi Mika¹,Matsumura Yasuko¹,Miyachi Hitoshi¹,Mise Nathan²,Abe Kuniya²,Ogura Atsuo²,Wilhelm Dagmar³,Koopman Peter³,Nozaki Masami⁴,Kanai Yoshiakira⁵,Shinkai Yoichi⁶,Tachibana Makoto¹⁷

Affiliation:

1. Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin, Kawara-cho, Sakyo-ku, Kyoto, Japan.

2. Bioresource Center, RIKEN Tsukuba Institute, 3-1-1 Koyadai, Tsukuba, Japan.

3. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

4. Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.

5. Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1-1-1, Bunkyoku, Tokyo 113-8657, Japan.

6. Cellular Memory Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

7. Graduate School of Biostudies, Kyoto University, 53 Shogoin, Kawara-cho, Sakyo-ku, Kyoto, Japan.

Abstract

More Determined Sex Although several transcription factors participate in mammalian sex determination, the contribution from specific epigenetic regulation is just being revealed. Kuroki et al. (p. 1106 ) show that a JmjC domain–containing protein, Jmjd1a, catalyzes H3K9 demethylation of the Y-linked sex-determining gene Sry in mice to enable its expression above the required threshold level. Ablation of Jmjd1a function results in mouse male-to-female sex reversal, hence not only revealing a mechanism of Sry regulation but also the pivotal role of epigenetic regulation in mammalian sex determination.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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