Sry: the master switch in mammalian sex determination-Reference-Cited by-同舟云学术

Sry: the master switch in mammalian sex determination

Published:2010-12-01 Issue:23 Volume:137 Page:3921-3930
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Kashimada Kenichi¹,Koopman Peter¹²

Affiliation:

1. Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

2. ARC Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

Abstract

SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which in turn drives testis formation. Here, we discuss the cascade of events triggered by SRY and the mechanisms that reinforce the differentiation of the testes in males while actively inhibiting ovarian development.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/137/23/3921/1202897/3921.pdf

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