AXR4 Is Required for Localization of the Auxin Influx Facilitator AUX1-Reference-Cited by-同舟云学术

AXR4 Is Required for Localization of the Auxin Influx Facilitator AUX1

Published:2006-05-26 Issue:5777 Volume:312 Page:1218-1220
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dharmasiri S.¹²³⁴,Swarup R.¹²³⁴,Mockaitis K.¹²³⁴,Dharmasiri N.¹²³⁴,Singh S. K.¹²³⁴,Kowalchyk M.¹²³⁴,Marchant A.¹²³⁴,Mills S.¹²³⁴,Sandberg G.¹²³⁴,Bennett M. J.¹²³⁴,Estelle M.¹²³⁴

Affiliation:

1. Department of Biology, Indiana University, Bloomington, IN 47405, USA.

2. School of Biosciences, University of Nottingham, Loughborough LE12 5RD, UK.

3. Umeå Plant Science Centre, SLU, Umeå, Sweden.

4. School of Computer Science and Information Technology, University of Nottingham, Nottingham NG7 2UH, UK.

Abstract

The AUX1 and PIN auxin influx and efflux facilitators are key regulators of root growth and development. For root gravitropism to occur, AUX1 and PIN2 must transport auxin via the lateral root cap to elongating epidermal cells. Genetic studies suggest that AXR4 functions in the same pathway as AUX1. Here we show that AXR4 is a previously unidentified accessory protein of the endoplasmic reticulum (ER) that regulates localization of AUX1 but not of PIN proteins. Loss of AXR4 resulted in abnormal accumulation of AUX1 in the ER of epidermal cells, indicating that the axr4 agravitropic phenotype is caused by defective AUX1 trafficking in the root epidermis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. Auxin Transport

2. Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation

3. Regulation of phyllotaxis by polar auxin transport

4. The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots

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