Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate-Reference-Cited by-同舟云学术

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

Published:2019-03-15 Issue:6432 Volume:363 Page:1217-1222
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chakraborty Abhishek A.¹^ORCID,Laukka Tuomas²^ORCID,Myllykoski Matti²^ORCID,Ringel Alison E.³^ORCID,Booker Matthew A.⁴^ORCID,Tolstorukov Michael Y.⁴^ORCID,Meng Yuzhong Jeff¹⁵⁶⁷⁸^ORCID,Meier Samuel R.⁵,Jennings Rebecca B.⁹^ORCID,Creech Amanda L.⁵^ORCID,Herbert Zachary T.¹⁰,McBrayer Samuel K.¹^ORCID,Olenchock Benjamin A.¹¹,Jaffe Jacob D.⁵^ORCID,Haigis Marcia C.³^ORCID,Beroukhim Rameen¹⁵⁷^ORCID,Signoretti Sabina⁹^ORCID,Koivunen Peppi²^ORCID,Kaelin William G.¹¹²^ORCID

Affiliation:

1. Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA.

2. Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, FIN-90014 Oulu, Finland.

3. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

4. Department of Informatics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

5. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

6. Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.

7. Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

8. The Harvard-MIT Program in Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.

9. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

10. Molecular Biology Core Facility, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA.

11. Division of Cardiovascular Medicine, Department of Medicine, The Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.

12. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

Oxygen sensing revisited The cellular response to hypoxia (oxygen deficiency) is a contributing factor in many human diseases. Previous studies examining the way in which hypoxia alters gene expression have focused on oxygen-sensing enzymes that regulate the activity of a transcription factor called hypoxia-inducible factor (see the Perspective by Gallipoli and Huntly). Chakraborty et al. and Batie et al. now show that hypoxia can also affect gene expression through direct effects on chromatin regulators. Certain histone demethylases, such as KDM6A and KDM5A, were found to be direct sensors of oxygen. In cell-culture models, hypoxia diminished the activity of these enzymes and caused changes in the expression of genes that govern cell fate. Science , this issue p. 1217 , p. 1222 ; see also p. 1148

Funder

National Institutes of Health

Academy of Finland

S. Juselius Foundation

Jane and Aatos Erkko Foundation

American Cancer Society

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference55 articles.