Somatic evolution and global expansion of an ancient transmissible cancer lineage-Reference-Cited by-同舟云学术

Somatic evolution and global expansion of an ancient transmissible cancer lineage

Published:2019-08-02 Issue:6452 Volume:365 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Baez-Ortega Adrian¹^ORCID,Gori Kevin¹^ORCID,Strakova Andrea¹^ORCID,Allen Janice L.²,Allum Karen M.³,Bansse-Issa Leontine⁴,Bhutia Thinlay N.⁵,Bisson Jocelyn L.¹⁶^ORCID,Briceño Cristóbal⁷^ORCID,Castillo Domracheva Artemio⁸,Corrigan Anne M.⁹,Cran Hugh R.¹⁰,Crawford Jane T.¹¹,Davis Eric¹²^ORCID,de Castro Karina F.¹³,B. de Nardi Andrigo¹⁴^ORCID,de Vos Anna P.¹⁵,Delgadillo Keenan Laura¹⁶,Donelan Edward M.²^ORCID,Espinoza Huerta Adela R.¹⁷^ORCID,Faramade Ibikunle A.¹⁸,Fazil Mohammed¹⁹^ORCID,Fotopoulou Eleni²⁰,Fruean Skye N.²¹,Gallardo-Arrieta Fanny²²,Glebova Olga²³,Gouletsou Pagona G.²⁴^ORCID,Häfelin Manrique Rodrigo F.²⁵,Henriques Joaquim J. G. P.²⁶^ORCID,Horta Rodrigo S.²⁷,Ignatenko Natalia²⁸,Kane Yaghouba²⁹,King Cathy³,Koenig Debbie³,Krupa Ada³⁰,Kruzeniski Steven J.¹⁷,Kwon Young-Mi¹,Lanza-Perea Marta⁹,Lazyan Mihran³¹,Lopez Quintana Adriana M.³²^ORCID,Losfelt Thibault³³,Marino Gabriele³⁴,Martínez Castañeda Simón³⁵^ORCID,Martínez-López Mayra F.³⁶³⁷^ORCID,Meyer Michael³⁸,Migneco Edward J.³⁹,Nakanwagi Berna⁴⁰,Neal Karter B.⁴¹,Neunzig Winifred³,Ní Leathlobhair Máire¹^ORCID,Nixon Sally J.⁴²,Ortega-Pacheco Antonio⁴³^ORCID,Pedraza-Ordoñez Francisco⁴⁴^ORCID,Peleteiro Maria C.⁴⁵,Polak Katherine⁴⁶,Pye Ruth J.⁴⁷^ORCID,Reece John F.⁴⁸,Rojas Gutierrez Jose⁴⁹,Sadia Haleema⁵⁰,Schmeling Sheila K.⁵¹^ORCID,Shamanova Olga⁵²,Sherlock Alan G.⁴⁷,Stammnitz Maximilian¹^ORCID,Steenland-Smit Audrey E.⁴,Svitich Alla⁵³,Tapia Martínez Lester J.¹⁷,Thoya Ngoka Ismail⁵⁴,Torres Cristian G.⁵⁵^ORCID,Tudor Elizabeth M.⁵⁶,van der Wel Mirjam G.⁵⁷,Viţălaru Bogdan A.⁵⁸,Vural Sevil A.⁵⁹^ORCID,Walkinton Oliver⁴⁷,Wang Jinhong¹^ORCID,Wehrle-Martinez Alvaro S.⁶⁰,Widdowson Sophie A. E.⁶¹,Stratton Michael R.⁶²^ORCID,Alexandrov Ludmil B.⁶³^ORCID,Martincorena Iñigo⁶²^ORCID,Murchison Elizabeth P.¹^ORCID

Affiliation:

1. Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

2. Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.

3. World Vets, Gig Harbor, USA.

4. Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.

5. Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, India.

6. Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin EH25 9RG, UK.

7. ConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.

8. Corozal Veterinary Hospital, University of Panamá, Panama City, Republic of Panama.

9. St. George's University, True Blue, Grenada.

10. The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.

11. Animal Medical Centre, Belize City, Belize.

12. International Animal Welfare Training Institute, UC Davis School of Veterinary Medicine, Davis, CA, USA.

13. Centro Universitário de Rio Preto (UNIRP), São José do Rio Preto, São Paulo, Brazil.

14. Department of Clinical and Veterinary Surgery, São Paulo State University (UNESP), São Paulo, Brazil.

15. Ladybrand Animal Clinic, Ladybrand, South Africa.

16. Veterinary Clinic Sr. Dog’s, Guadalajara, Mexico.

17. World Vets Latin America Veterinary Training Center, Granada, Nicaragua.

18. National Veterinary Research Institute, Vom, Nigeria.

19. Animal Clinic, Mombasa, Kenya.

20. Intermunicipal Stray Animals Care Centre (DIKEPAZ), Perama, Greece.

21. Animal Protection Society of Samoa, Apia, Samoa.

22. Faculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela.

23. Veterinary Clinic BIOCONTROL, Moscow, Russia.

24. Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece.

25. Veterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago de Chile, Chile.

26. OnevetGroup, Hospital Veterinário Berna, Lisboa, Portugal.

27. Universidade Vila Velha, Vila Velha, Brazil.

28. Veterinary Clinic Zoovetservis, Kiev, Ukraine.

29. École Inter-états des Sciences et Médecine Vétérinaires de Dakar, Dakar, Senegal.

30. Department of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

31. Vetexpert Veterinary Group, Yerevan, Armenia.

32. Veterinary Clinic Lopez Quintana, Maldonado, Uruguay.

33. Clinique Veterinaire de Grand Fond, Saint Gilles les Bains, Reunion, France.

34. Department of Veterinary Sciences, University of Messina, Messina, Italy.

35. Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.

36. School of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador.

37. Cancer Development and Innate Immune Evasion Lab, Champalimaud Center for the Unknown, Lisbon, Portugal.

38. Touray & Meyer Vet Clinic, Serrekunda, The Gambia.

39. Hillside Animal Hospital, St. Louis, MO, USA.

40. The Kampala Veterinary Surgery, Kampala, Uganda.

41. Asavet Veterinary Charities, Tucson, AZ, USA.

42. Vets Beyond Borders, Bylakuppe, India.

43. Faculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico.

44. Laboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.

45. Interdisciplinary Centre of Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal.

46. Four Paws International, Vienna, Austria.

47. Vets Beyond Borders, The Rocks, Australia.

48. Help in Suffering, Jaipur, India.

49. Veterinary Clinic Dr José Rojas, Los Andes, Chile.

50. Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan.

51. Corozal Veterinary Clinic, Corozal Town, Belize.

52. Veterinary Clinic Vetmaster, Ramenskoye, Russia.

53. State Hospital of Veterinary Medicine, Dniprodzerzhynsk, Ukraine.

54. Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.

55. Laboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile

56. Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Australia.

57. Animal Anti Cruelty League, Port Elizabeth, South Africa.

58. Clinical Sciences Department, Faculty of Veterinary Medicine Bucharest, Bucharest, Romania.

59. Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.

60. Faculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay.

61. Lilongwe Society for Protection and Care of Animals (LSPCA), Lilongwe, Malawi.

62. Wellcome Sanger Institute, Hinxton, UK.

63. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.

Abstract

It's a dog's life Canine transmissible venereal tumor is one of the few cancer lineages that is transferred among individuals through contact. It arose millennia ago and has been evolving independently from its hosts ever since. Baez-Ortega et al. looked at the phylogenetic history of the cancer and describe several distinctive mutational patterns (see the Perspective by Maley and Shibata). Most notably, both positive and negative selection show only weak or distant signals. This suggests that the main driver of the lineage's evolution is neutral genetic drift. Understanding the influence of drift may reshape how we think about long-term cancer evolution. Science , this issue p. eaau9923 ; see also p. 440

Funder

Wellcome

Leverhulme Trust

Kennel Club Charitable Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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