Structure of a transcribing RNA polymerase II–U1 snRNP complex-Reference-Cited by-同舟云学术

Structure of a transcribing RNA polymerase II–U1 snRNP complex

Published:2021-01-15 Issue:6526 Volume:371 Page:305-309
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhang Suyang¹^ORCID,Aibara Shintaro¹^ORCID,Vos Seychelle M.¹^ORCID,Agafonov Dmitry E.²^ORCID,Lührmann Reinhard²,Cramer Patrick¹^ORCID

Affiliation:

1. Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

2. Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

Abstract

A tight couple makes messenger RNAs Gene expression in eukaryotes first requires transcription of DNA to an RNA copy and then splicing to form the final, processed messenger RNA (mRNA). Zhang et al. investigated how gene transcription and RNA splicing are physically coupled. Using cryo–electron microscopy, they resolved the molecular structure of a complex of the transcription enzyme RNA polymerase II with part of the splicing machinery, the U1 small nuclear ribonucleoprotein particle. The results provide important details for our understanding of coupled mRNA production. Science , this issue p. 305

Funder

European Molecular Biology Organization

H2020 Marie Skłodowska-Curie Actions

European Research Council

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference47 articles.

1. Cotranscriptional Recruitment of the U1 snRNP to Intron-Containing Genes in Yeast

2. Cotranscriptional Spliceosome Assembly Dynamics and the Role of U1 snRNA:5′ss Base Pairing in Yeast