Sustained virologic control in SIV + macaques after antiretroviral and α 4 β 7 antibody therapy-Reference-Cited by-同舟云学术

Sustained virologic control in SIV + macaques after antiretroviral and α 4 β 7 antibody therapy

Published:2016-10-14 Issue:6309 Volume:354 Page:197-202
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Byrareddy Siddappa N.¹,Arthos James²,Cicala Claudia²,Villinger Francois¹³,Ortiz Kristina T.¹,Little Dawn¹,Sidell Neil⁴,Kane Maureen A.⁵,Yu Jianshi⁵,Jones Jace W.⁵,Santangelo Philip J.⁶,Zurla Chiara⁶,McKinnon Lyle R.⁷,Arnold Kelly B.⁸,Woody Caroline E.⁸,Walter Lutz⁹,Roos Christian⁹,Noll Angela⁹,Van Ryk Donald²,Jelicic Katija²,Cimbro Raffaello¹⁰,Gumber Sanjeev³,Reid Michelle D.¹,Adsay Volkan¹,Amancha Praveen K.³,Mayne Ann E.¹,Parslow Tristram G.¹,Fauci Anthony S.²,Ansari Aftab A.¹

Affiliation:

1. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

2. Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD 20892, USA.

3. Division of Pathology, The Yerkes National Primate Center of Emory University, Atlanta, GA 30329, USA.

4. Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, GA 30322, USA.

5. Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA.

6. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30680, USA.

7. Centre for the AIDS Program of Research in South Africa (CAPRISA), Durban, South Africa.

8. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

9. Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.

10. Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD 21201, USA.

Abstract

Antibodies sustain viral control For many infected individuals, antiretroviral therapy (ART) means that an HIV-1 diagnosis is no longer a death sentence. But the virus persists in treated individuals, and complying with the intense drug regimen to keep virus loads down can be challenging for patients. Seeking an alternative, Byrareddy et al. treated ART-suppressed monkeys with antibodies targeting α4β7 integrin. When ART was halted in the antibody-treated animals, viral loads stayed undetectable, and normal CD4 T cell counts were maintained for over 9 months—and persisted—even after stopping the antibody therapy. Science , this issue p. 197 Update: An Editorial Expression of Concern has been published here

Funder

NIAID-NIH

U.S. Food and Drug Administration

Yerkes National Primate Research Center of Emory University

University of Maryland School of Pharmacy Mass Spectrometry Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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