Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus-Reference-Cited by-同舟云学术

Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus

Published:2021-03-12 Issue:6534 Volume:371 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zepp Jarod A.¹²³⁴^ORCID,Morley Michael P.¹²³^ORCID,Loebel Claudia⁵^ORCID,Kremp Madison M.¹²³,Chaudhry Fatima N.⁴^ORCID,Basil Maria C.¹²^ORCID,Leach John P.¹²³^ORCID,Liberti Derek C.¹²³⁶^ORCID,Niethamer Terren K.¹²³^ORCID,Ying Yun¹²³^ORCID,Jayachandran Sowmya⁷,Babu Apoorva¹²³^ORCID,Zhou Su¹²³^ORCID,Frank David B.²³⁷^ORCID,Burdick Jason A.⁵^ORCID,Morrisey Edward E.¹²³^ORCID

Affiliation:

1. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

2. Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

3. Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

4. Division of Pulmonary Medicine, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

5. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

6. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

7. Division of Pediatric Cardiology, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

Transitioning lung for postnatal life The lung is a complex organ composed of multiple cell types, and its alveolus serves as the functional unit of gas exchange. The alveolar type 1 cell (AT1) serves as an active signaling hub in the developing and postnatal mouse and human lung. Zepp et al. generated a comprehensive single-cell atlas of the developing murine lung and identified cell differentiation and cell-to-cell communication as the lung transitions to air breathing. The AT1 cells spatially aligned with stromal progenitors and formed a signaling hub that preferentially communicated with a transient, force-exerting, myofibroblast through signaling factors including Shh and Wnts to actively remodel the alveolus after the transition to air breathing. Science , this issue p. eabc3172

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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