Programming DNA Tube Circumferences

Author:

Yin Peng12345,Hariadi Rizal F.12345,Sahu Sudheer12345,Choi Harry M. T.12345,Park Sung Ha12345,LaBean Thomas H.12345,Reif John H.12345

Affiliation:

1. Department of Computer Science, California Institute of Technology, Pasadena, CA 91125, USA.

2. Department of Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA.

3. Center for Biological Circuit Design, California Institute of Technology, Pasadena, CA 91125, USA.

4. Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA.

5. Center for the Physics of Information, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes displaying monodisperse circumferences of 4, 5, 6, 7, 8, 10, or 20 DNA helices.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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