Shisa7 is a GABA A receptor auxiliary subunit controlling benzodiazepine actions-Reference-Cited by-同舟云学术

Shisa7 is a GABA A receptor auxiliary subunit controlling benzodiazepine actions

Published:2019-10-11 Issue:6462 Volume:366 Page:246-250
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Han Wenyan¹^ORCID,Li Jun¹^ORCID,Pelkey Kenneth A.²^ORCID,Pandey Saurabh¹^ORCID,Chen Xiumin³^ORCID,Wang Ya-Xian⁴,Wu Kunwei¹^ORCID,Ge Lihao⁵^ORCID,Li Tianming¹^ORCID,Castellano David¹^ORCID,Liu Chengyu⁶^ORCID,Wu Ling-Gang⁵,Petralia Ronald S.⁴,Lynch Joseph W.³^ORCID,McBain Chris J.²^ORCID,Lu Wei¹^ORCID

Affiliation:

1. Synapse and Neural Circuit Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

2. Cellular and Synaptic Neuroscience Section, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

3. Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.

4. Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.

5. Synaptic Transmission Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

6. Transgenetic Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Fine control of brain GABA A receptors GABA A (γ-aminobutyric acid type A) receptors are ligand-gated anion channels that mediate fast inhibitory transmission in the mammalian brain. Han et al. investigated if a protein called SHISA7 was involved in regulating GABA A receptor expression and function (see the Perspective by Rudolph and Moss). SHISA7 was found at GABA-releasing synapses, where it interacted with GABA A receptors, controlled receptor concentration at the synapse, sped up receptor deactivation kinetics, and modulated some behavioral properties of benzodiazepines. SHISA7 thus affects surface expression, gating kinetics, and pharmacology of GABA A receptors in the brain. Science , this issue p. 246 ; see also p. 185

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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